Article
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.
Proceedings of the National Academy of Sciences of the United States of America - 18 May 2004
Zhu Yanan, Swanson Bradley J, Wang Michael, Hildeman David A, Schaefer Brian C, Liu Xinqi, Suzuki Hiroyuki, Mihara Katsuyoshi, Kappler John, Marrack Philippa
Abstract excerpt
Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and apoptotic T cells is associated with mitochondria, not microtubules. In healthy resting T cells Bim is bound to the antiapoptotic proteins Bcl-2 and Bcl-x(L). In activated T cells,...
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