Article
Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.
Blood - 8 Apr 2010
Will Britta, Siddiqi Tanya, Jordà Meritxell Alberich, Shimamura Takeshi, Luptakova Katarina, Staber Philipp B, Costa Daniel B, Steidl Ulrich, Tenen Daniel G, Kobayashi Susumu
Abstract excerpt
The activating mutation JAK2 V617F plays a central role in the pathogenesis of polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Inhibition of JAK2 activity leads to growth inhibition and apoptosis in cells with mutated JAK2. However, the proapoptotic proteins involved in J...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.