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Article

Polymorphisms within inflammatory genes and colorectal cancer.

Journal of negative results in biomedicine - 24 Oct 2006

Landi Stefano, Gemignani Federica, Bottari Fabio, Gioia-Patricola Lydie, Guino Elisabet, Cambray María, Biondo Sebastiano, Capella Gabriel, Boldrini Laura, Canzian Federico, Moreno Victor

Abstract excerpt

BACKGROUND: Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1...

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Source

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Identifiers

PMID: 17062130
DOI: 10.1186/1477-5751-5-15
PMCID: PMC1634873

Genes

PTGS1
TLR4
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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