Article
Haplotype variation and linkage disequilibrium in 313 human genes.
Science (New York, N.Y.) - 20 Jul 2001
Stephens J C, Schneider J A, Tanguay D A, Choi J, Acharya T, Stanley S E, Jiang R, Messer C J, Chew A, Han J H, Duan J, Carr J L, Lee M S, Koshy B, Kumar A M, Zhang G, Newell W R, Windemuth A, Xu C, Kalbfleisch T S, Shaner S L, Arnold K, Schulz V, Drysdale C M, Nandabalan K, Judson R S, Ruano G, Vovis G F
Abstract excerpt
Variation within genes has important implications for all biological traits. We identified 3899 single nucleotide polymorphisms (SNPs) that were present within 313 genes from 82 unrelated individuals of diverse ancestry, and we organized the SNPs into 4304 different haplotypes. Each gene had several variable SNPs and haplotypes that were present in all populations, as well as a number that were...
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