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Article

Genetic architecture of Hsp90-dependent drug resistance.

Eukaryotic cell - 1 Dec 2006

Cowen Leah E, Carpenter Anne E, Matangkasombut Oranart, Fink Gerald R, Lindquist Susan

Abstract excerpt

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17056742
DOI: 10.1128/EC.00274-06
PMCID: PMC1694807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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