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Extensive functional redundancy in the regulation of C andida albicans drug resistance and morphogenesis by lysine deacetylases H os2, H da1, R pd3 and R pd31

21 Nov 2016

Abstract excerpt

Current treatment efforts for fungal infections are hampered by the limited availability of antifungal drugs and by the emergence of drug resistance. A powerful strategy to enhance the efficacy of antifungal drugs is to inhibit the molecular chaperone Hsp90. Hsp90 governs drug resistance, morphogenesis and virulence in a leading fungal pathogen of humans, Candida albicans. Our previous work with Saccharomyces...

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PMID: 27868254
DOI: 10.1111/mmi.13578

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