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Article

An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology.

Cancer research - 15 Mar 2004

Zhu Yong, Spitz Margaret R, Amos Christopher I, Lin Jie, Schabath Matthew B, Wu Xifeng

Abstract excerpt

Given that there are millions of single-nucleotide polymorphisms (SNPs) in the entire human genome, a major difficulty faced by scientists in planning costly population-based genotyping is to choose target SNPs that are most likely to affect phenotypic functions and ultimately contribute to disease development. Although it is widely accepted that sequences with important functionality tend to be less variable...

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Identifiers

PMID: 15026370
DOI: 10.1158/0008-5472.can-03-2800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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