Article
Association between the MnSOD Ala-9Val polymorphism and development of schizophrenia and abnormal involuntary movements in the Xhosa population.
Progress in neuro-psychopharmacology & biological psychiatry - 13 Apr 2007
Hitzeroth Angelika, Niehaus Dana J H, Koen Liezl, Botes Willem C, Deleuze J F, Warnich Louise
Abstract excerpt
Reactive oxygen species (ROS)-mediated damage has been hypothesized to play a role in the development and poor outcome of schizophrenia, as well as the development of neuroleptic-induced abnormal involuntary movements. Recently, the functional polymorphism (Ala-9Val) in the manganese superoxide dismutase (MnSOD) gene (part of the antioxidant defense mechanism) was found to be associated with schizophrenia in a...
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