Article
Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with age of smoking initiation in male schizophrenia smokers.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2016
Zhang Xiang Yang, Rao Wen-Wang, Yu Qiong, Yu Yaqin, Kou Changgui, Tan Yun-Long, Chen Da-Chun, Zuo Lingjun, Luo Xiangguang, Soares Jair C
Abstract excerpt
Schizophrenia patients exhibit higher smoking rates than the general population. A growing body of evidence suggests that cigarette smoke impairs the antioxidant defense mechanisms, leading to oxidative damage. Manganese superoxide dismutase (MnSOD) is the major antioxidant in the mitochondria, catalyzing the metabolism of superoxide radicals to form hydrogen peroxide. Since the identification of a...
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