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Article

IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2007

Nguyen Cuong Q, Gao Jue-hua, Kim Hyuna, Saban Daniel R, Cornelius Janet G, Peck Ammon B

Abstract excerpt

NOD.B10-H2(b) and NOD/LtJ mice manifest, respectively, many features of primary and secondary Sjögren's syndrome (SjS), an autoimmune disease affecting primarily the salivary and lacrimal glands leading to xerostomia (dry mouth) and xerophthalmia (dry eyes). B lymphocytes play a central role in the onset of SjS with clinical manifestations dependent on the appearance of autoantibodies reactive to multiple...

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Source

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Identifiers

PMID: 17579059
DOI: 10.4049/jimmunol.179.1.382
PMCID: PMC2856075

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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