Article
Development and clinical evaluation of oligonucleotide microarray for HLA-AB genotyping.
Pharmacogenomics - 1 Oct 2006
Zhang Fan, Hu Shouwang, Huang Jian, Wang Hui, Wen Zheng, Yongyao Geng, Wang Shengqi
Abstract excerpt
BACKGROUND: The antigens encoded by human leukocyte antigen (HLA) genes are primary antigens in immunological response of transplantation, and genotypes of HLA-A, B and DRB1 must be determined on donors and recipients before the transplantation is carried out. In this study, oligonucleotide microarray for HLA-AB genotyping was prepared and evaluated. METHODS: Oligonucleotide probes were designed based on the...
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