Article
HTRA1 promoter polymorphism in wet age-related macular degeneration.
Science (New York, N.Y.) - 10 Nov 2006
Dewan Andrew, Liu Mugen, Hartman Stephen, Zhang Samuel Shao-Min, Liu David T L, Zhao Connie, Tam Pancy O S, Chan Wai Man, Lam Dennis S C, Snyder Michael, Barnstable Colin, Pang Chi Pui, Hoh Josephine
Abstract excerpt
Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular). Inherited variation in the complement factor H gene is a major risk factor for drusen in dry AMD. Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on...
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