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Article

PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders.

Neurobiology of aging - 1 Jan 2008

Yaffe K, Kanaya A M, Lindquist K, Hsueh W C, Cummings S R, Beamer B, Newman A, Rosano C, Li R, Harris T

Abstract excerpt

BACKGROUND: The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. We tested whether this polymorphism is associated with cognition. METHODS: Two thousand nine hundred sixty-one participants (mean age, 74.1; 41% Black; 52% women) were administered the Modified...

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Identifiers

PMID: 17052804
DOI: 10.1016/j.neurobiolaging.2006.09.010
PMCID: PMC2233891

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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