Article
Mitochondrial damages and the regulation of insulin secretion.
Biochemical Society transactions - 1 Nov 2006
Maechler P, de Andrade P B M
Abstract excerpt
Pancreatic beta-cells are able to respond to nutrients, principally glucose, as the primary stimulus for insulin exocytosis. This unique feature requires translation of metabolic substrates into intracellular messengers recognized by the exocytotic machinery. Central to this signal transduction mechanism, mitochondria integrate and generate metabolic signals, thereby coupling glucose recognition with insulin...
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