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Article

The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma.

Blood - 24 Feb 2011

Rossi Davide, Rasi Silvia, Di Rocco Alice, Fabbri Alberto, Forconi Francesco, Gloghini Annunziata, Bruscaggin Alessio, Franceschetti Silvia, Fangazio Marco, De Paoli Lorenzo, Bruna Riccardo, Capello Daniela, Chiappella Annalisa, Lobetti Bodoni Chiara, Giachelia Manuela, Tisi Maria Chiara, Pogliani Enrico M, Lauria Francesco, Ladetto Marco, Hohaus Stefan, Martelli Maurizio, Vitolo Umberto, Carbone Antonino, Foà Robin, Gaidano Gianluca

Abstract excerpt

Several drugs used for diffuse large B-cell lymphoma (DLBCL) treatment rely on DNA damage for tumor cell killing. We verified the prognostic impact of the host DNA repair genotype in 2 independent cohorts of DLBCL treated with R-CHOP21 (training cohort, 163 cases; validation cohort, 145 cases). A...

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Source

Identifiers

PMID: 21156845
DOI: 10.1182/blood-2010-07-296244

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21156845-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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