Article
Analysis of linkage between lymphotoxin alpha haplotype and polymorphisms in 5'-flanking region of tumor necrosis factor alpha gene associated with efficacy of infliximab for Crohn's disease patients.
Mutation research - 1 Dec 2006
Ozeki Takeshi, Furuya Yoko, Nagano Chieko, Matsui Chika, Takayanagi Risa, Yokoyama Haruko, Yamada Yasuhiko
Abstract excerpt
Tumor necrosis factor (TNF)alpha is increased in patients with Crohn's disease (CD) and considered to play an important role in the inflammation. Infliximab (IFX) is used as a therapeutic agent for CD. Recently, it was reported that homozygosity for a lymphotoxin alpha (LTA) haplotype (LTA 1-1-1-...
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