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Article

Effects of tumor necrosis factor α-857C/T polymorphism on the expression of tumor necrosis factor α.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Aug 2016

Kimura Koji, Takayanagi Risa, Yokoyama Haruko, Yamada Yasuhiko

Abstract excerpt

It was reported that homozygosity for a lymphotoxin α (LTA) 1-1-1-1 haplotype (LTA NcoI-TNFc-aa13L-aa26) may identify subgroups with a poor response to infliximab in Crohn's disease patients. Previously, we found a genetic polymorphism that linked with the LTA 1-1-1-1 haplotype and noted that it was a tumor necrosis factor (TNF) α-857 T allele. To investigate the effects of the -857C/T (rs1799724) polymorphism on...

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PMID: 27307133
DOI: 10.1111/apm.12559

Genes

LTA
TNF

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