Article
Vesicular glutamate transporter contains two independent transport machineries.
The Journal of biological chemistry - 22 Dec 2006
Juge Narinobu, Yoshida Yumi, Yatsushiro Shouki, Omote Hiroshi, Moriyama Yoshinori
Abstract excerpt
Vesicular glutamate transporters (VGLUTs) are responsible for the vesicular storage of l-glutamate and play an essential role in glutamatergic signal transmission in the central nervous system. The molecular mechanism of the transport remains unknown. Here, we established a novel in vitro assay procedure, which includes purification of wild and mutant VGLUT2 and their reconstitution with purified bacterial...
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