Article
Screening for genetic modifiers of amyloid toxicity in yeast.
Methods in enzymology - 1 Jan 2006
Giorgini Flaviano, Muchowski Paul J
Abstract excerpt
In recent years the facile, yet powerful, genetics of the baker's yeast Saccharomyces cerevisiae has been appropriated for the study of amyloid toxicity. Several models of amyloid toxicity using this simple eukaryotic organism have been developed that faithfully recapitulate many disease-relevant phenotypes. Furthermore, these models have been exploited in genetic screens that have provided insight into conserved...
Topics
- Amyloid
- Gene Expression Regulation, Fungal
- Genetic Testing
- Models, Genetic
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transformation, Genetic