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Article

Endothelial cell COX-2 expression and activity in hypoxia.

Biochimica et biophysica acta - 1 Dec 2006

Cook-Johnson Rebecca J, Demasi Maryanne, Cleland Leslie G, Gamble Jennifer R, Saint David A, James Michael J

Abstract excerpt

The clinical experience with selective cyclooxygenase (COX)-2 inhibitors reveals there are important protective roles for COX-2 in the cardiovascular system. This study examined the response to hypoxia of endothelial cell eicosanoid synthesis with respect to the role of COX-2 and its molecular regulation in hypoxia. Human umbilical vein endothelial cells (HUVEC) were exposed to hypoxia and the effects on COX-2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17046322
DOI: 10.1016/j.bbalip.2006.09.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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