Article
Donor cell differentiation, reprogramming, and cloning efficiency: Elusive or illusive correlation?
12 Oct 2006
Abstract excerpt
Compared to other assisted reproductive technologies, mammalian nuclear transfer (NT) cloning is inefficient in generating viable offspring. It has been postulated that nuclear reprogramming and cloning efficiency can be increased by choosing less differentiated cell types as nuclear donors. This hypothesis is mainly supported by comparative mouse cloning experiments using early blastomeres, embryonic stem (ES)...
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