Article
Climbing Mount Efficiency – Small Steps, Not Giant Leaps Towards Higher Cloning Success in Farm Animals
1 Jul 2008
Abstract excerpt
Despite more than a decade of research efforts, farm animal cloning by somatic cell nuclear transfer (SCNT) is still frustratingly inefficient. Inefficiency manifests itself at different levels, which are currently not well integrated. At the molecular level, it leads to widespread genetic, epigenetic and transcriptional aberrations in cloned embryos. At the organismal level, these genome-wide abnormalities...
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