Donor Cells for Nuclear Cloning: Many Are Called, but Few Are Chosen

Abstract excerpt

The few viable clones obtained at the end of a typical cloning experiment are genetic copies of the donor cell genome of a non-reproductive (somatic) or embryonic cell used for nuclear transfer. Nuclear totipotency has to be reestablished by erasing epigenetic constraints imposed on the donor genome during differentiation in a process which involves active chromatin remodeling. Various donor cell types and cell...

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