Article
A mutant chaperone converts a wild-type protein into a tumor-specific antigen.
Science (New York, N.Y.) - 13 Oct 2006
Schietinger Andrea, Philip Mary, Yoshida Barbara A, Azadi Parastoo, Liu Hui, Meredith Stephen C, Schreiber Hans
Abstract excerpt
Monoclonal antibodies have become important therapeutic agents against certain cancers. Many tumor-specific antigens are mutant proteins that are predominantly intracellular and thus not readily accessible to monoclonal antibodies. We found that a wild-type transmembrane protein could be transformed into a tumor-specific antigen. A somatic mutation in the chaperone gene Cosmc abolished function of a...
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