Article
Androgen receptor mutations are associated with Gleason score in localized prostate cancer.
BJU international - 1 Dec 2006
Sanchez Daniel, Rosell David, Honorato Beatriz, Lopez Jorge, Arocena Juan, Sanz Gonzalo
Abstract excerpt
OBJECTIVE: To study human androgen receptor (hAR) mutations and their relationship to the clinical and pathological characteristics of patients with prostate cancer, as the mechanisms by which tumour cells escape androgen control and grow independently of hormone stimulation are unclear. PATIENTS AND METHODS: In all, 67 radical prostatectomy specimens were sequenced genomically (mean age of the patients, 64...
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