Article
Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.
American journal of hematology - 1 Mar 2007
Nolan Vikki G, Ma Qianli, Cohen Herbert T, Adewoye Adeboye, Rybicki Anne C, Baldwin Clinton, Mahabir Rhea N, Homan Erica P, Wyszynski Diego F, Fabry Mary E, Nagel Ronald L, Farrer Lindsay A, Steinberg Martin H
Abstract excerpt
Renal disease is common in sickle cell anemia. In this exploratory work, we used data from a longitudinal study of the natural history of sickle cell disease to examine the hypothesis that polymorphisms (SNPs) in selected candidate genes are associated with glomerular filtration rate (GFR). DNA samples and clinical and laboratory data were available for 1,140 patients with sickle cell anemia. GFR was estimated...
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