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Article

Evidence that Microdeletions in the α Globin Gene Protect Against the Development of Sickle Cell Glomerulopathy in Humans

1 May 1999

Abstract excerpt

There is a large variability in the severity of the clinical manifestations of sickle cell anemia (SSA), including renal involvement. Haplotypes in the beta-globin gene cluster associated with the geographical origin of the sickle mutation, as well as microdeletions in the alpha-globin genes, could provide an epigenetic influence on the heterogeneous outcome in SSA. It has been determined that the cause of...

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PMID: 10232687
DOI: 10.1681/asn.v1051014

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Evidence that Microdeletions in the α Globin Gene Protect Against the Development of Sickle Cell Glomerulopathy in HumansPMID 10232687Read ↗

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Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.Semantic proximity Read ↗

Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease.Semantic proximity Read ↗

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