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Article

Membrane Topology of the Hepatitis C Virus NS2 Protein

30 Aug 2002

Abstract excerpt

The hepatitis C virus (HCV) NS2 protein is a hydrophobic protein. Previous studies indicate that this protein is an integral membrane protein, which is targeted to the membrane of the endoplasmic reticulum (ER) by the signal sequence located in its preceding p7 protein. In this report, we demonstrate that the membrane association of NS2 is p7-independent and occurs co-translationally. Further deletion-mapping...

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PMID: 12082096
DOI: 10.1074/jbc.m202304200

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