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Article

An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.

The Journal of biological chemistry - 8 Mar 2002

Brass Volker, Bieck Elke, Montserret Roland, Wölk Benno, Hellings Jan Albert, Blum Hubert E, Penin François, Moradpour Darius

Abstract excerpt

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A), a phosphoprotein of unknown function, is believed to be a component of a membrane-associated viral replication complex. The determinants for membrane association of NS5A, however, have not been defined. By double label immunofluorescence analyses, NS5A was found to be associated with the endoplasmic reticulum (ER) or an ER-derived modified compartment both...

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Identifiers

PMID: 11744739
DOI: 10.1074/jbc.M111289200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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