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Article

Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice.

Genome biology - 21 Sept 2011

Hilton Jennifer M, Lewis Morag A, Grati M'hamed, Ingham Neil, Pearson Selina, Laskowski Roman A, Adams David J, Steel Karen P

Abstract excerpt

BACKGROUND: Inflammation of the middle ear (otitis media) is very common and can lead to serious complications if not resolved. Genetic studies suggest an inherited component, but few of the genes that contribute to this condition are known. Mouse mutants have contributed significantly to the identification of genes predisposing to otitis media RESULTS: The dearisch mouse mutant is an ENU-induced mutant detected...

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Source

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Identifiers

PMID: 21936904
DOI: 10.1186/gb-2011-12-9-r90
PMCID: PMC3308053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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