Deciphering molecular mechanisms of metastasis: novel insights into targets and therapeutics.

Abstract excerpt

BACKGROUND: The transition of a primary tumour to metastatic progression is driven by dynamic molecular changes, including genetic and epigenetic alterations. The metastatic cascade involves bidirectional interactions among extracellular and intracellular components leading to disintegration of cellular junctions, cytoskeleton reorganization and epithelial to mesenchymal transition. These events promote...

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