Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limited proteolysis of human histone deacetylase 1.

BMC biochemistry - 5 Oct 2006

Kamath Nayana, Karwowska-Desaulniers Paulina, Pflum Mary Kay H

Abstract excerpt

BACKGROUND: Histone deacetylase (HDAC) proteins are associated with cell proliferation, differentiation, apoptosis, and cancer. Specifically, HDAC1 is linked with cell growth, a hallmark of cancer formation. HDAC1 is a phosphoprotein and phosphorylation at S421 and S423 promotes HDAC1 enzymatic activity and protein association. While single and double point mutants of HDAC1 at S421 and S423 appear functionally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Gene Expression
Share to Histone Deacetylase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Jurkat Cells

Share to Phosphorylation

Share to Protein Binding

Share to Trypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 17022812
DOI: 10.1186/1471-2091-7-22
PMCID: PMC1613246

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limited proteolysis of human histone deacetylase 1.PMID 17022812Read ↗

Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.Semantic proximity Read ↗

Developing potent PROTACs tools for selective degradation of HDAC6 proteinSemantic proximity Read ↗

A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective InhibitorsSemantic proximity Read ↗

Screening for therapeutic targets of vorinostat by SILAC‐based proteomic analysis in human breast cancer cellsSemantic proximity Read ↗

Kinetics and Comparative Reactivity of Human Class I and Class IIb Histone DeacetylasesSemantic proximity Read ↗

Proteasome-dependent degradation of histone H1 subtypes is mediated by its C-terminal domainSemantic proximity Read ↗

The emergence of regulated histone proteolysis.Semantic proximity Read ↗

HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.Semantic proximity Read ↗

Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor.Semantic proximity Read ↗

Chemical proteomics profiling of proteasome activity.Semantic proximity Read ↗

Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule.Semantic proximity Read ↗

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone DeacetylasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.