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Article

Kinetics and Comparative Reactivity of Human Class I and Class IIb Histone Deacetylases

1 Aug 2004

Abstract excerpt

Histone deacetylase (HDAC) enzymes modulate gene expression through the deacetylation of acetylated lysine residues on histone proteins. They operate in biological systems as part of multiprotein corepressor complexes. To understand the reactivity of isolated HDACs and the contribution of cofactor binding to reactivity, the reaction kinetics of isolated, recombinant human HDACs 1, 2, 3, 6, 8, and 10 were measured...

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PMID: 15323567
DOI: 10.1021/bi0494471

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