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Article

The carrier Msn5p/Kap142p promotes nuclear export of the hsp70 Ssa4p and relocates in response to stress.

Molecular microbiology - 1 Oct 2006

Quan XinXin, Tsoulos Panagiotis, Kuritzky Alexandra, Zhang Rui, Stochaj Ursula

Abstract excerpt

Cytoplasmic hsp70s like yeast Ssa4p shuttle between nucleus and cytoplasm under normal growth conditions but accumulate in nuclei upon stress. This nuclear accumulation is only transient, and Ssa4p relocates to the cytoplasm when cells recover. We show here that Ssa4p nuclear export is independent of Xpol/Crm1 and identify the importin-beta family member Msn5p/Kap142p as the exporter for Ssa4p. In growing cells...

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PMID: 17020589
DOI: 10.1111/j.1365-2958.2006.05395.x

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