Article
Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus.
The American journal of pathology - 1 Dec 1990
Feichtinger H, Putkonen P, Parravicini C, Li S L, Kaaya E E, Böttiger D, Biberfeld G, Biberfeld P
Abstract excerpt
Malignant lymphomas were observed in 38% (9 of 24) of simian immunodeficiency virus (SIV)-infected cynomolgus monkeys (Macaca fascicularis) 5 to 15 months after inoculation with SIV strain SMM3. Lymphomagenesis in the SIV-infected monkeys was not related directly to the SIV-infectious dose given. All SIV-infected animals developed severe immunodeficiency. No significant difference in immunodeficiency was observed...
Topics
- Animals
- Antigens, CD
- B-Lymphocytes
- CD4 Antigens
- Female
- Immunohistochemistry
- Lymph Nodes
- Lymphoma
- Macaca fascicularis
- Male
- Phenotype
- Simian Acquired Immunodeficiency Syndrome