Article
Monocyte/macrophage giant cell disease in SIV-infected cynomolgus monkeys.
Research in virology - 1 Jan 2000
Li S L, Kaaya E E, Feichtinger H, Putkonen P, Parravicini C, Böttiger D, Biberfeld G, Biberfeld P
Abstract excerpt
A non-opportunistic, generalized giant cell disease (GCD) was found in 12 out of 25 (48%) cynomologus monkeys infected with SIVsm. Most organs were affected notably the lymph nodes (LN), spleen, gut, liver, lungs and CNS. The multinucleated GC varied considerably in cell size and in the number and cytoplasmic distribution of the nuclei. Immunohistochemically most GC expressed SIV antigens and markers of...
Topics
- Animals
- Antigens, Viral
- Giant Cells
- Immunohistochemistry
- Macaca fascicularis
- Macrophages
- Monocytes
- Organ Specificity
- Phenotype
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus