Evaluating candidate agents of selective pressure for cystic fibrosis.

Abstract excerpt

Cystic fibrosis is the most common lethal single-gene mutation in people of European descent, with a carrier frequency upwards of 2%. Based upon molecular research, resistances in the heterozygote to cholera and typhoid fever have been proposed to explain the persistence of the mutation. Using a population genetic model parameterized with historical demographic and epidemiological data, we show that neither...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Causality
• Share to Comorbidity
• Share to Cystic Fibrosis