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Article

Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory.

BMC infectious diseases - 12 May 2017

Bosch Lander, Bosch Barbara, De Boeck Kris, Nawrot Tim, Meyts Isabelle, Vanneste Dominique, Le Bourlegat Cleonice Alexandre, Croda Julio, da Silva Filho Luiz Vicente Ribeiro Ferreira

Abstract excerpt

BACKGROUND: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis (Mtb) infection. METHODS: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis (TB) incidence in Brazil. We corrected...

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Identifiers

PMID: 28499359
DOI: 10.1186/s12879-017-2448-z
PMCID: PMC5429554

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CFTR

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