Article
Do delta F508 heterozygotes have a selective advantage?
Genetical research - 1 Aug 2001
Wiuf C
Abstract excerpt
In this paper the fitness of the delta F508 heterozygote is assessed and the age of the delta F508 mutation in the cystic fibrosis locus is estimated. Data from three microsatellite loci are applied. The analysis is performed conditional on the present-day frequency of the delta F508 mutation and based on assumptions about the demographic history of the European population and the mutation rate in the three...
Topics
- Biological Evolution
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Heterozygote
- Humans
- Microsatellite Repeats
- Models, Genetic
- Mutation
- Time Factors