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Article

Historical Intensity of Natural Selection for Resistance to Tuberculosis

1 Aug 2002

Abstract excerpt

Infections have long been thought to exert natural selection on humans. Infectious disease resistance is frequently invoked as a mechanism shaping human genetic diversity, but such hypotheses have rarely been quantitatively evaluated with direct measures of disease-related mortality. Enhancement of genetically determined resistance to tuberculosis by natural selection has been proposed as a factor explaining the...

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PMID: 12196403
DOI: 10.1093/genetics/161.4.1599

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