Genetic and geographical variability in cystic fibrosis: evolutionary considerations.

doi:10.1002/9780470514887.ch6

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Article

Genetic and geographical variability in cystic fibrosis: evolutionary considerations.

Ciba Foundation symposium - 1 Jan 1996

Bertranpetit J, Calafell F

Abstract excerpt

We have studied cystic fibrosis from an evolutionary perspective by focusing on three main points: the high frequency of cystic fibrosis; the different spectrum of mutations that cause the disease in different areas of Europe; and the age of the delta F508 mutation. Several hypotheses have been s...

Topics

Cystic Fibrosis
Evolution, Molecular
Genetic Variation
Geography
Humans
Mutation

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