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Article

Low-grade slightly elevated and polypoid colorectal adenomas display differential β-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression.

World journal of gastroenterology - 7 May 2017

Yang Tian-Wen, Gao Yun-Han, Ma Sha-Ying, Wu Qiang, Li Zhong-Fu

Abstract excerpt

AIM: To comparatively investigate the cellular and molecular characteristics of low-grade slightly elevated adenomas and polypoid adenomas. METHODS: Colorectal tumors were collected from 24 patients with slightly elevated adenomas and 23 patients with polypoid adenomas. Five commonly mutated genes (APC, BRAF, KRAS, NRAS, and PIK3CA) were selected for mutational analysis. Paraffin-embedded tumor sections were used...

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Identifiers

PMID: 28533663
DOI: 10.3748/wjg.v23.i17.3066
PMCID: PMC5423043

Genes

APC
KRAS
BRAF
NRAS

Provenance

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