Article
The vasostatin-1 fragment of chromogranin A preserves a quiescent phenotype in hypoxia-driven endothelial cells and regulates tumor neovascularization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2011
Veschini Lorenzo, Crippa Luca, Dondossola Eleonora, Doglioni Claudio, Corti Angelo, Ferrero Elisabetta
Abstract excerpt
The angiogenic switch is a fundamental process for many diseases and for tumor growth. The main proangiogenic stimulus is hypoxia, through activation of the hypoxia-inducible factor (HIF)-1α pathway in endothelial cells (ECs). We have previously shown that the vasostatin-1 (VS-1) fragment of chromogranin A inhibits TNF-α-induced vessel permeability and VEGF-induced EC proliferation, together with migration and...
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