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Article

Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response.

Neuroscience letters - 5 Dec 2008

Tzang Ruu-Fen, Hong Chen-Jee, Liou Ying-Jay, Yu Younger W-Y, Chen Tai-Jui, Tsai Shih-Jen

Abstract excerpt

The p11 protein (also called S100A10), which plays a pivotal role in the dynamic modulation of serotonergic 1B receptor function, has been implicated in the pathogenesis of major depressive disorder (MDD) and the therapeutic mechanisms of antidepressant action. Humans and mice with depression have lower central p11 levels, and treatment with antidepressant agents raises p11 levels in animals. Furthermore, brain...

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Identifiers

PMID: 18838110
DOI: 10.1016/j.neulet.2008.09.063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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