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Article

Association of pharmacodynamic genes with treatment outcomes in major depressive disorder: results from a Sardinian cohort.

The pharmacogenomics journal - 23 Apr 2025

Paribello Pasquale, Manchia Mirko, Pinna Marco, Contu Martina, Orrù Davide, Upali Marco, El Kacemi Sabrina, Frau Ilaria, Suprani Federico, Corrias Carolina, Somaini Giulia, Pinna Federica, Pisanu Claudia, Meloni Anna, Carta Andrea, Conversano Claudio, Mola Francesco, Del Zompo Maria, Buson Lisa, Gennarelli Massimo, Minelli Alessandra, Carpiniello Bernardo, Squassina Alessio

Abstract excerpt

We examined the association of selected candidate pharmacodynamic (PD) genes in MDD with treatment outcomes, defined according to remission thresholds for Hamilton Depression Rating Scale (HDRS) with 6- and 17- items. To this end, we recruited 158 individuals living with MDD followed in an academic community mental health center. We reconstructed their clinical history and tested the association of a selected...

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PMID: 40263270
DOI: 10.1038/s41397-025-00373-2

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