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Article

Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.

Journal of virology - 1 Oct 2006

Heck Elke, Friedrich Ute, Gack Michaela U, Lengenfelder Doris, Schmidt Monika, Müller-Fleckenstein Ingrid, Fleckenstein Bernhard, Ensser Armin, Biesinger Brigitte

Abstract excerpt

Lymphoma induction and T-cell transformation by herpesvirus saimiri strain C488 depends on two viral oncoproteins, StpC and Tip. The major interaction partner of Tip is the protein tyrosine kinase Lck, a key regulator of T-cell activation. The Lck binding domain (LBD) of Tip comprises two interaction motifs, a proline-rich SH3 domain-binding sequence (SH3B) and a region with homology to the C terminus of Src...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

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Identifiers

PMID: 17005671
DOI: 10.1128/JVI.01112-06
PMCID: PMC1617286

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