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A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice.

Oncogene - 18 Apr 1996

Kretschmer C, Murphy C, Biesinger B, Beckers J, Fickenscher H, Kirchner T, Fleckenstein B, Rüther U

Abstract excerpt

Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of transgenic mice. Expression of two different constructs caused the development of peripheral...

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PMID: 8622880

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