Article
A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice.
Oncogene - 18 Apr 1996
Kretschmer C, Murphy C, Biesinger B, Beckers J, Fickenscher H, Kirchner T, Fleckenstein B, Rüther U
Abstract excerpt
Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction...
Topics
- Animals
- Bacterial Proteins
- Base Sequence
- Blotting, Northern
- CD3 Complex
- CD4 Antigens
- Cloning, Molecular
- DNA-Binding Proteins
- Escherichia coli Proteins
- Gene Expression
- Herpesvirus 2, Saimiriine
- Immunohistochemistry
