Article
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ACS chemical biology - 16 Mar 2018
Ye Fei, Kong Xiangqian, Zhang Hao, Liu Yan, Shao Zhiyuan, Jin Jia, Cai Yi, Zhang Rukang, Li Linjuan, Zhang Yang W, Liu Yu-Chih, Zhang Chenhua, Xie Wenbing, Yu Kunqian, Ding Hong, Zhao Kehao, Chen Shijie, Jiang Hualiang, Baylin Stephen B, Luo Cheng
Abstract excerpt
DNA methyltransferase-1 (DNMT1) plays a crucial role in the maintenance of genomic methylation patterns. The crystal structure of DNMT1 was determined in two different states in which the helix that follows the catalytic loop was either kinked (designated helix-kinked) or well folded (designated helix-straight state). Here, we show that the proper structural transition between these two states is required for...
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