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Article

Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies.

Science translational medicine - 6 Jan 2016

Singh Nathan, Perazzelli Jessica, Grupp Stephan A, Barrett David M

Abstract excerpt

Engineered T cell therapies have begun to demonstrate impressive clinical responses in patients with B cell malignancies. Despite this efficacy, many patients are unable to receive T cell therapy because of failure of in vitro expansion, a necessary component of cell manufacture and a predictor of in vivo activity. To evaluate the biology underlying these functional differences, we investigated T cell expansion...

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Identifiers

PMID: 26738796
DOI: 10.1126/scitranslmed.aad5222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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