Article
Clonal lymphoid progenitor cell lines expressing the BCR/ABL oncogene retain full differentiative function.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990
Scherle P A, Dorshkind K, Witte O N
Abstract excerpt
The early stages of hematopoiesis have been difficult to study due to problems in obtaining homogeneous populations of progenitor cells that retain both self-renewal and differentiative capacities. We have developed an in vitro system in which transformation of murine bone-marrow cells with the B...
Topics
- Animals
- B-Lymphocytes
- Bone Marrow
- Cell Differentiation
- Cell Line
- Cells, Cultured
- Fusion Proteins, bcr-abl
- Hematopoietic Stem Cells
- Immunologic Deficiency Syndromes
- Interleukin-7
- Lymphocytes
- Mice