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Article

Clonal lymphoid progenitor cell lines expressing the BCR/ABL oncogene retain full differentiative function.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

Scherle P A, Dorshkind K, Witte O N

Abstract excerpt

The early stages of hematopoiesis have been difficult to study due to problems in obtaining homogeneous populations of progenitor cells that retain both self-renewal and differentiative capacities. We have developed an in vitro system in which transformation of murine bone-marrow cells with the BCR/ABL oncogene, a gene associated with stem-cell leukemias, leads to the outgrowth of clonal lines that have an early...

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Identifiers

PMID: 2408044
DOI: 10.1073/pnas.87.5.1908
PMCID: PMC53593

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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